
Originally Posted by
Parabens, Estrogen, and LOLOMG oh MY!
Every so often I hear about chemicals that are now thought to be on the prowl in order to, you know, KILL. Things that everyone thought were completely safe turn out to be little molecular Charlie Mansons. The latest OMG SCARY PANIC chemicals are parabens.
Parabens are a group of chemicals that have been used for a long, LONG time in preserving everything from food to cosmetics, and generally are considered extremely safe. There have been no studies showing anything really dangerous about them, but people are still worried about it based on the fact that in very, very large amounts it parabens have been shown to cause some very, very weak increases in estrogen. OMG PANIC!
Well, wait. Don't panic yet.
From the wikipedia article on parabens -
Animal experiments have shown that parabens have weak estrogenic activity, acting as xenoestrogens.[15] In an in vivo study, the effect of butylparaben was determined to be approximately 100,000 times weaker than estradiol, although this effect was only observed when employing a dose level which was 25,000 times higher than is actually used to preserve products.[16] As the estrogenic effect is dose-related, it may be calculated that the estrogenic effect at normal use concentrations of butylparaben is 100,000 x 25,000, i.e. 2,500,000,000 times weaker than estradiol. In the same study it was shown that the in vivo estrogenic activity of parabens is reduced by about three orders of magnitude compared to in vitro activity probably through the rapid metabolism of the parabens to the non-estrogenic metabolites. In vivo data are accepted as being more relevant than in vitro data.
Translation: The estrogen-like effects are ONLY observed when levels 25000 times higher than amounts used in preserving products were employed. The level observed was then REALLY FRICKING WEAK.
Boiled down: Shut up.
If you take ANYTHING in 25,000 times its normal usage there's bound to be an effect or 3. Take 10,000,000 milligrams of Ibuprofen, as an example - that would be, yes, 10 KILOGRAMS of ibuprofen. That's the level of dilution we're talking about here.
Reality: Not just for breakfast anymore!
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