Those 340s are totally unnessary for self defense. They are hard to control and tough to make a follow-up shot with. I would rather have some mild 240 magnums or .44 Special rounds for that. Possibly even 180-210 grain loads
I handload cast 240 gr LSWC at 1100 fps. They will shoot thru a deer from chest to tail. 900-1100 fps with a 240 is plenty for man stopping.
Anacondas have gotten too high to buy. I have a sizeable collection of Colts, but rarely buy them anymore due to the pricing...if I were in the market today, I would buy a 629 Classic.
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I like Ruger firearms; my GP 100 ranks up there as one of the best pistols I've ever owned.
Smith & Wesson makes a decent pistol as well. My 629 handles 230 grain Hornady rounds quite well, but they can raise hell with your hand after a box of 50.