I am too late to answer this question since you've already made your choice and are happy, but I have both the Grande and Regular Muhle handles. I do not have large hands or small hands...just normal. I prefer the length of the Grande handle, but the diameter of the regular Muhle handle. I have a bit of nerve damage in my extremities, and the Grande handle makes my hands hurt for some reason by the end of the shave. The regular diameter is just perfect for me, but I prefer a slightly longer handle.
The only real disappointment I have with the Muhle is the handle really doesn't have much grip. It looks like it would when viewing it on the internet, but the knurling is so shallow as to really offer almost no grip at all, compared to a lot of other handles. Outside of that, Muhle makes an outstanding razor and the shave is fantastic.
Store the razor tightened down on the blade. Taking it apart and cleaning everything after each shave is a good idea. Just make sure to pat the blade only, don't wipe it. If you do, you risk removing any coating the maker may have put on the blade edge to help it shave more smoothly. Also, by wiping you may accidentally dull the edge if you were to run the towel down the edge of the blade or something. Rinse well, pat dry, re-assemble...no problems.
Jeff - I'm a "Newoholic". GNÜ (Gillette NEW Über-fan), BOTOC
Trust men and they will be true to you; treat them greatly and they will show themselves great." - Ralph Waldo Emerson