I was just reading an ad about the EMP just today! Very nice gun Leatherneck. I am a veteran police officer in Oklahoma, and have owned many different type of guns. It kind of makes me chuckle when I see people argue about brands, types, calibers and ballistics. My wife has her CCW because she is a Retail Manager and makes night drops at the bank. She carries a Ruger LCP in 380.
Most gun fights, especially self defense situations, are under 3 seconds and between 7 yards and point blank range, with multiple shots fired. Carry the gun you like people. Carry the caliber you want, like, and are comfortable with and know you will hit the target with. .45 to .22 people, it really is about shot placement. shoot until the threat has stopped. Remember, self defense is just that, anything further than you grabbing a hand full of hair of an attacker, and shoving the gun into their neck is going to be decided if it is justifiable homicide by a jury of your peers. The jury room is an unpredictable thing people, know this.
.45 is a large bullet. Shoot until the threat stops. a .380 is a small bullet. shoot until the threat stops. The .380 killed Tupac & Biggie. Hell, I don't want to get shot with a BB gun in my pinkie toe... :)
Remember the old adage: Beware of the man with just one gun... He probably knows how to use it.